Primary Literature Articles

1.     Takeda AJ, Zhang Y, Dornan GL, Siempelkamp BD, Jenkins ML, Matthews HF, McElwee JJ, Bi W, Seeborg FO, Su HC, Burke JE, and Lucas CL.  (2017). Novel PIK3CD mutations affecting N-terminal residues of p110d cause hyperactive PI3K signaling and APDS1 in humans. J Allergy Clin Immunol. 2017 Apr 13. pii: S0091-6749(17)30587-0. PUBMED LINK

2.    Dornan GL, Siempelkamp BD, Jenkins ML, Vadas O, Lucas CL, and Burke JE.  (2017). Conformational disruption of PI3Kd regulation by immunodeficiency mutations in PIK3CD and PIK3R1. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1982-1987. PUBMED LINK

3.    Elkaim E, Neven B, Bruneau J, Mitsui-Sekinaka K, Stanislas A, Heurtier L, Lucas CL, Matthews H, Deau MC, Sharapova S, Curtis J, Reichenbach J, Glastre C, Parry DA, Arumugakani G, McDermott E, Kilic SS, Yamashit M, Moshous D, Lamrini H, Otremba B, Gennery A, Coulter T, Quinti I, Stephan JL, Lougaris V, Brodszki N, Barlogis V, Asano T, Galicier L, Boutboul D, Nonoyama S, Cant A, Imai K, Picard C, Nejentsev S, Molina TJ, Lenardo M, Savic S, Cavazzana M, Fischer A, Durandy A, Kracker S. (2016). Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase delta syndrome 2: A cohort study. Journal of Allergy and Clinical Immunology. 138(1):210-218. PUBMED LINK

4.    Lucas CL, Zhang Y, Venida A, Wang Y, Hughes J, McElwee J, Butrick M, Matthews M, Price S, Biancalana M, Wang X, Richards M, Pozos T, Barlan I, Ozen A, Rao VK, Su HC, Lenardo MJ.  (2014). Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K. Journal of Experimental Medicine. 211(13):2537-47. Epub 2014 Dec 8. PUBMED LINK

5.    Lucas CL*, Kuehn HS*, Zhao F*, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MG, and Uzel G. *Shared first authorship. (2014). Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110d result in T cell senescence and human immunodeficiency. Nature Immunology. 15(1):88-97. Epub 2013 Oct 28. PUBMED LINK

6.    Chaigne-Delalande B, Li F-Y, O’Connor GM, Lukacs M, Biancalana M, Zheng L, Shatzer A, Pittaluga S, Matthews HF, Jancel T, Hetherington M, Bleesing JJ, Kuijpers TW, Lucas CL, Nagpal S, Mehmet H, Su HC, Cohen JI, Uzel G, and Lenardo MJ. (2013). Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science. 341(6142):186-91. PUBMED LINK

7.    Haspot F*, Li HW*, Lucas CL*, Fehr T, Beyaz S, and Sykes M. *Shared first authorship. (2013). Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells. American Journal of Transplantation. 14(1):49-58. PUBMED LINK

8.    Lo B, Swafford ADE, Shafer-Weaver KA, Jerome LF, Rakhlin L, Mathern DR, Callahan CA, Jiang P, Davison LJ, Stevens HE, Lucas CL, White J, von Borstel R, Todd JA, and Lenardo MJ. (2011). Antibodies against insulin measured by electrochemiluminescence predict insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status. Journal of Translational Medicine. 9:203. PUBMED LINK

9.    Lucas CL, Workman CJ, Beyaz S, LoCascio S, Zhao G, Vignali DAA, and Sykes M.  (2011). LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T cell tolerance induced by allogeneic BMT with anti-CD40L. Blood. 117(20):5532-40. PUBMED LINK

10.  Hermanrud C, Lucas CL, Sykes M, Huang CA, and Wang Z.  (2011). Construction, expression and purification of the soluble single chain murine CD40 ligand monomer, dimer and trimer in yeast Pichia pastoris. Protein Expression and Purification. 76(1):115-20. PUBMED LINK

11.   Fehr T*, Lucas CL*, Kurtz J, Onoe T, Zhao G, Hogan T, Vallot C, Rao A, Sykes M. *Shared first authorship. (2010).  A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivoBlood.  115(6):1280-7. PUBMED LINK

12.   Mollov J*, Lucas CL*, Haspot F*, Kurtz J, Gaspar C, Guzman A, Sykes M. *Shared first authorship. (2010). Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8 T cell tolerance. American Journal of Transplantation. 10(3):518-26. PUBMED LINK

13.   Haspot F, Fehr T, Gibbons C, Zhao G, Hogan T, Honjo T, Freeman G, Sykes M. (2008).  Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.  Blood. 112(5): 2149-55. PUBMED LINK

14.   Dackor RT, Fritz-Six K, Dunworth W, Gibbons C, Smithies O, Caron KM. (2006). Hydrops fetalis, cardiovascular defects and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Molecular and Cellular Biology. 26(7): 2511-8. PUBMED LINK


Reviews, Commentaries, and Book Chapters

  1. Carpier JM and Lucas CL.  EBV susceptibility in Activated PI3Kdelta Syndrome (APDS) immunodeficiency. Frontiers in Immunology.  2017 Dec;16. ARTICLE LINK
  2.  Lucas CL, Chandra A, Nejentsev S, Condliffe AM, and Okkenhaug K. (2016).  Activating PI3Kd mutations and primary immunodeficiency. Nature Reviews Immunology.  2016 Nov;16(11):702-14. PUBMED LINK
  3. Lenardo M, Lo B, and Lucas CL. (2016). Genomics of immune diseases and new therapies. Annual Review of Immunology.  2016 May 20;34:121-49. Epub 2015 Dec 23. PUBMED LINK
  4. Lucas CL and Lenardo MJ. (2015). Identifying genetic determinants of autoimmunity and immune dysregulation.  Current Opinions in Immunology.  37:28-33. Epub 2015 Oct 2. PUBMED LINK
  5. Lucas CL and Lenardo MJ. (2013).  Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis.  Chapter in Cell Death: Mechanism and Disease.  Springer Science.  Editor: Hao Wu. SPRINGER LINK
  6. Lucas CL and Sykes M. (2011). Layers of regulation in induction of mixed chimerism by anti-CD40L. Chimerism. 2(4):111-113. PUBMED LINK
  7. Del Rio ML, Lucas CL, Rayat G, Buhler L, Rodriguez-Barboza JI. (2009). HVEM/BTLA/CD160/LIGHT co-signaling pathways as targets for immune regulation. Journal of Leukocyte Biology. 87(2):223-35. PUBMED LINK
  8. Del Rio ML, Buhler L, Gibbons C, Tian J, Rodriguez-Barboza JI. (2008).  PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transplant International. 21(11):1015-28. PUBMED LINK
  9. Gibbons C and Sykes M. (2008). Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.  Immunological Reviews. 223:334-60. PUBMED LINK
  10. Gibbons C, Dackor R, Dunworth W, Fritz-Six K, Caron KM. (2007).  Receptor activity-modifying proteins: “RAMP”ing up adrenomedullin signaling.  Molecular Endocrinology.  21(4): 783-96. PUBMED LIN